Publications

2006

Segal, D. J., J. W. Crotty, M. S. Bhakta, C. F. Barbas, and N. C. Horton, "Structure of Aart, a designed six-finger zinc finger peptide, bound to DNA.", J Mol Biol, vol. 363, issue 2, pp. 405-21, 2006 Oct 20. PMID: 16963084
Bild, A. H., G. Yao, J. T. Chang, Q. Wang, A. Potti, D. Chasse, M-B. Joshi, D. Harpole, J. M. Lancaster, A. Berchuck, et al., "Oncogenic pathway signatures in human cancers as a guide to targeted therapies.", Nature, vol. 439, issue 7074, pp. 353-7, 2006 Jan 19. PMID: 16273092
Joshi, H. K., C. Etzkorn, L. Chatwell, J. Bitinaite, and N. C. Horton, "Alteration of sequence specificity of the type II restriction endonuclease HincII through an indirect readout mechanism.", J Biol Chem, vol. 281, issue 33, pp. 23852-69, 2006 Aug 18. PMID: 16675462
Buchan, J.R., L. S. Aucott, and I. Stansfield, "tRNA properties help shape codon pair preferences in open reading frames.", Nucleic Acids Res, vol. 34, issue 3, pp. 1015-27, 2006. PMCID: PMC1363775  PMID: 16473853

2005

Bolger, T. A., and T-P. Yao, "Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death.", J Neurosci, vol. 25, issue 41, pp. 9544-53, 2005 Oct 12. PMCID: PMC6725694  PMID: 16221865
Lopez, J. I., T. D. Camenisch, M. V. Stevens, B. J. Sands, J. McDonald, and J. A. Schroeder, "CD44 attenuates metastatic invasion during breast cancer progression.", Cancer Res, vol. 65, issue 15, pp. 6755-63, 2005 Aug 01. PMID: 16061657
Zhao, X., T. Sternsdorf, T. A. Bolger, R. M. Evans, and T-P. Yao, "Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications.", Mol Cell Biol, vol. 25, issue 19, pp. 8456-64, 2005 Oct. PMCID: PMC1265742  PMID: 16166628
Delong, M., G. Yao, Q. Wang, A. Dobra, E. P. Black, J. T. Chang, A. Bild, M. West, J. R. Nevins, and H. Dressman, "DIG--a system for gene annotation and functional discovery.", Bioinformatics, vol. 21, issue 13, pp. 2957-9, 2005 Jul 01. PMID: 15870167
Crotty, J. W., C. Etzkorn, C. F. Barbas, D. J. Segal, and N. C. Horton, "Crystallization and preliminary X-ray crystallographic analysis of Aart, a designed six-finger zinc-finger peptide, bound to DNA.", Acta Crystallogr Sect F Struct Biol Cryst Commun, vol. 61, issue Pt 6, pp. 573-6, 2005 Jun 01. PMCID: PMC1952332  PMID: 16511099
Little, E. J., and N. C. Horton, "DNA-induced conformational changes in type II restriction endonucleases: the structure of unliganded HincII.", J Mol Biol, vol. 351, issue 1, pp. 76-88, 2005 Aug 05. PMID: 15993893

2004

Etzkorn, C., and N. C. Horton, "Ca2+ binding in the active site of HincII: implications for the catalytic mechanism.", Biochemistry, vol. 43, issue 42, pp. 13256-70, 2004 Oct 26. PMID: 15491133
Yao, G., M. Craven, N. Drinkwater, and C. A. Bradfield, "Interaction networks in yeast define and enumerate the signaling steps of the vertebrate aryl hydrocarbon receptor.", PLoS Biol, vol. 2, issue 3, pp. E65, 2004 Mar. PMCID: PMC368161  PMID: 15024417
Horton, N. C., and J. J. Perona, "DNA cleavage by EcoRV endonuclease: two metal ions in three metal ion binding sites.", Biochemistry, vol. 43, issue 22, pp. 6841-57, 2004 Jun 08. PMID: 15170321
Schroeder, J. A., A. Al Masri, M. C. Adriance, J. C. Tessier, K. L. Kotlarczyk, M. C. Thompson, and S. J. Gendler, "MUC1 overexpression results in mammary gland tumorigenesis and prolonged alveolar differentiation.", Oncogene, vol. 23, issue 34, pp. 5739-47, 2004 Jul 29. PMID: 15221004
Etzkorn, C., and N. C. Horton, "Mechanistic insights from the structures of HincII bound to cognate DNA cleaved from addition of Mg2+ and Mn2+.", J Mol Biol, vol. 343, issue 4, pp. 833-49, 2004 Oct 29. PMID: 15476804
Hattrup, C. L., J. Fernandez-Rodriguez, J. A. Schroeder, G. C. Hansson, and S. J. Gendler, "MUC1 can interact with adenomatous polyposis coli in breast cancer.", Biochem Biophys Res Commun, vol. 316, issue 2, pp. 364-9, 2004 Apr 02. PMID: 15020226

2003

Schroeder, J. A., L. F. Jackson, D. C. Lee, and T. D. Camenisch, "Form and function of developing heart valves: coordination by extracellular matrix and growth factor signaling.", J Mol Med (Berl), vol. 81, issue 7, pp. 392-403, 2003 Jul. PMID: 12827270
Schroeder, J. A., M. C. Adriance, M. C. Thompson, T. D. Camenisch, and S. J. Gendler, "MUC1 alters beta-catenin-dependent tumor formation and promotes cellular invasion.", Oncogene, vol. 22, issue 9, pp. 1324-32, 2003 Mar 06. PMID: 12618757

2002

Horton, N. C., L. F. Dorner, and J. J. Perona, "Sequence selectivity and degeneracy of a restriction endonuclease mediated by DNA intercalation.", Nat Struct Biol, vol. 9, issue 1, pp. 42-7, 2002 Jan. PMID: 11742344
Horton, N. C., C. Otey, S. Lusetti, M. D. Sam, J. Kohn, A. M. Martin, V. Ananthnarayan, and J. J. Perona, "Electrostatic contributions to site specific DNA cleavage by EcoRV endonuclease.", Biochemistry, vol. 41, issue 35, pp. 10754-63, 2002 Sep 03. PMID: 12196013
Camenisch, T. D., J. A. Schroeder, J. Bradley, S. E. Klewer, and J. A. McDonald, "Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors.", Nat Med, vol. 8, issue 8, pp. 850-5, 2002 Aug. PMID: 12134143

2001

Schroeder, J. A., M. C. Thompson, M. M. Gardner, and S. J. Gendler, "Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland.", J Biol Chem, vol. 276, issue 16, pp. 13057-64, 2001 Apr 20. PMID: 11278868
Fazio, I. K., T. A. Bolger, and G. Gill, "Conserved regions of the Drosophila erect wing protein contribute both positively and negatively to transcriptional activity.", J Biol Chem, vol. 276, issue 22, pp. 18710-6, 2001 Jun 01. PMID: 11278998
Sam, M. D., N. C. Horton, T. A. Nissan, and J. J. Perona, "Catalytic efficiency and sequence selectivity of a restriction endonuclease modulated by a distal manganese ion binding site.", J Mol Biol, vol. 306, issue 4, pp. 851-61, 2001 Mar 02. PMID: 11243793
Horton, N. C., and J. J. Perona, "Making the most of metal ions.", Nat Struct Biol, vol. 8, issue 4, pp. 290-3, 2001 Apr. PMID: 11276242

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