Joyce Schroeder

Department Head, Molecular and Cellular Biology
Professor, Molecular and Cellular Biology
Professor, BIO5 Institute
Professor, Cancer Biology - GIDP
Professor, Genetics - GIDP

My research interests are in the area of breast cancer progression and invasion. Transgenic mouse models of spontaneous carcinoma are used to understand the molecular mechanisms of primary tumor development and metastatic progression. Tumor growth and invasion is a complex process requiring the use of animal models to accurately recapitulate tumor formation and spread so that we can properly investigate the molecular mechanisms of cancer.

My work focuses on investigating the mechanisms by which erbB (EGFR) activity is modified in cancer, including interactions with MUC1 and CD44. She also explores changes in polarity that occurs between normal and transformed epithelium. To fully understand the molecular changes that occur in cancer, my research also focuses on these molecules as they affect the development and function of the normal mammary gland. My lab is also working towards the development of peptide-based therapies to block tumor-promoting protein-protein interactions as cancer therapeutics.

Publications

2019

Maisel, S. A., D. Broka, B. Atwell, T. Bunch, R. Kupp, S. K. Singh, S. Mehta, and J. Schroeder, "Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer.", J Transl Med, vol. 17, issue 1, pp. 201, 2019 06 18. PMCID: PMC6582486 PMID: 31215437

2018

Daniel, S. G., A. D. Russ, K. M. Guthridge, A. I. Raina, P. S. Estes, L. M. Parsons, H. E. Richardson, J. A. Schroeder, and D. C. Zarnescu, "mediates the role of Lethal giant larvae as an epithelial growth inhibitor in .", Biol Open, vol. 7, issue 1, 2018 Jan 26. PMCID: PMC5829493 PMID: 29361610
Maisel, S., D. Broka, and J. Schroeder, "Intravesicular epidermal growth factor receptor subject to retrograde trafficking drives epidermal growth factor-dependent migration.", Oncotarget, vol. 9, issue 5, pp. 6463-6477, 2018 Jan 19. PMCID: PMC5814225 PMID: 29464085

2016

Buehler, J., S. Zeltzer, J. Reitsma, A. Petrucelli, M. Umashankar, M. Rak, P. Zagallo, J. Schroeder, S. Terhune, and F. Goodrum, "Opposing Regulation of the EGF Receptor: A Molecular Switch Controlling Cytomegalovirus Latency and Replication.", PLoS Pathog, vol. 12, issue 5, pp. e1005655, 2016 05. PMCID: PMC4878804 PMID: 27218650
Greenwood, E., S. Maisel, D. Ebertz, A. Russ, R. Pandey, and J. Schroeder, "Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration.", Oncotarget, vol. 7, issue 38, pp. 60776-60792, 2016 Sep 20. PMCID: PMC5308616 PMID: 27542214

2014

Zheng, X., L. Jiang, J. Schroeder, A. Stopeck, and Y. Zohar, "Isolation of viable cancer cells in antibody-functionalized microfluidic devices.", Biomicrofluidics, vol. 8, issue 2, pp. 024119, 2014 Mar. PMCID: PMC4008759 PMID: 24803968

2013

Horm, T. M., and J. A. Schroeder, "MUC1 and metastatic cancer: expression, function and therapeutic targeting.", Cell Adh Migr, vol. 7, issue 2, pp. 187-98, 2013 Mar-Apr. PMCID: PMC3954031 PMID: 23303343
Hart, M. R., H-Y. Su, D. Broka, A. Goverdhan, and J. A. Schroeder, "Inactive ERBB receptors cooperate with reactive oxygen species to suppress cancer progression.", Mol Ther, vol. 21, issue 11, pp. 1996-2007, 2013 Nov. PMCID: PMC3831044 PMID: 24081029

2012

Horm, T. M., B. G. Bitler, D. M. Broka, J. M. Louderbough, and J. A. Schroeder, "MUC1 drives c-Met-dependent migration and scattering.", Mol Cancer Res, vol. 10, issue 12, pp. 1544-54, 2012 Dec. PMCID: PMC3528822 PMID: 23193156
Russ, A., J. M. V. Louderbough, D. Zarnescu, and J. A. Schroeder, "Hugl1 and Hugl2 in mammary epithelial cells: polarity, proliferation, and differentiation.", PLoS One, vol. 7, issue 10, pp. e47734, 2012. PMCID: PMC3479147 PMID: 23110097

2011

Louderbough, J. M. V., and J. A. Schroeder, "Understanding the dual nature of CD44 in breast cancer progression.", Mol Cancer Res, vol. 9, issue 12, pp. 1573-86, 2011 Dec. PMID: 21970856
Zheng, X., L. Siu- Lun Cheung, J. A. Schroeder, L. Jiang, and Y. Zohar, "Cell receptor and surface ligand density effects on dynamic states of adhering circulating tumor cells.", Lab Chip, vol. 11, issue 20, pp. 3431-9, 2011 Oct 21. PMCID: PMC6765388 PMID: 21853194
Zheng, X., L. Siu- Lun Cheung, J. A. Schroeder, L. Jiang, and Y. Zohar, "A high-performance microsystem for isolating circulating tumor cells.", Lab Chip, vol. 11, issue 19, pp. 3269-76, 2011 Oct 07. PMCID: PMC6765387 PMID: 21837324
Louderbough, J. M. V., J. A. Brown, R. B. Nagle, and J. A. Schroeder, "CD44 Promotes Epithelial Mammary Gland Development and Exhibits Altered Localization during Cancer Progression.", Genes Cancer, vol. 2, issue 8, pp. 771-81, 2011 Aug. PMCID: PMC3278897 PMID: 22393462

2010

Louderbough, J. M. V., J. I. Lopez, and J. A. Schroeder, "Matrix hyaluronan alters epidermal growth factor receptor-dependent cell morphology.", Cell Adh Migr, vol. 4, issue 1, pp. 26-31, 2010 Jan-Mar. PMCID: PMC2852554 PMID: 20009574
Flowers, M., J. A. Schroeder, A. D. Borowsky, D. G. Besselsen, C. A. Thomson, R. Pandey, and P. A. Thompson, "Pilot study on the effects of dietary conjugated linoleic acid on tumorigenesis and gene expression in PyMT transgenic mice.", Carcinogenesis, vol. 31, issue 9, pp. 1642-9, 2010 Sep. PMCID: PMC2930807 PMID: 20624750
Bitler, B. G., and J. A. Schroeder, "Anti-cancer therapies that utilize cell penetrating peptides.", Recent Pat Anticancer Drug Discov, vol. 5, issue 2, pp. 99-108, 2010 Jun. PMCID: PMC7485746 PMID: 19961434
Bitler, B. G., A. Goverdhan, and J. A. Schroeder, "MUC1 regulates nuclear localization and function of the epidermal growth factor receptor.", J Cell Sci, vol. 123, issue Pt 10, pp. 1716-23, 2010 May 15. PMCID: PMC2864713 PMID: 20406885

2009

Cheung, L. Siu Lun, X. Zheng, A. Stopa, J. C. Baygents, R. Guzman, J. A. Schroeder, R. L. Heimark, and Y. Zohar, "Detachment of captured cancer cells under flow acceleration in a bio-functionalized microchannel.", Lab Chip, vol. 9, issue 12, pp. 1721-31, 2009 Jun 21. PMID: 19495456
Bitler, B. G., I. Menzl, C. L. Huerta, B. Sands, W. Knowlton, A. Chang, and J. A. Schroeder, "Intracellular MUC1 peptides inhibit cancer progression.", Clin Cancer Res, vol. 15, issue 1, pp. 100-9, 2009 Jan 01. PMCID: PMC2676873 PMID: 19118037

2007

Pochampalli, M. R., B. G. Bitler, and J. A. Schroeder, "Transforming growth factor alpha dependent cancer progression is modulated by Muc1.", Cancer Res, vol. 67, issue 14, pp. 6591-8, 2007 Jul 15. PMID: 17638868
Pochampalli, M. R., R. M. el Bejjani, and J. A. Schroeder, "MUC1 is a novel regulator of ErbB1 receptor trafficking.", Oncogene, vol. 26, issue 12, pp. 1693-701, 2007 Mar 15. PMID: 16983337

2005

Lopez, J. I., T. D. Camenisch, M. V. Stevens, B. J. Sands, J. McDonald, and J. A. Schroeder, "CD44 attenuates metastatic invasion during breast cancer progression.", Cancer Res, vol. 65, issue 15, pp. 6755-63, 2005 Aug 01. PMID: 16061657

2004

Schroeder, J. A., A. Al Masri, M. C. Adriance, J. C. Tessier, K. L. Kotlarczyk, M. C. Thompson, and S. J. Gendler, "MUC1 overexpression results in mammary gland tumorigenesis and prolonged alveolar differentiation.", Oncogene, vol. 23, issue 34, pp. 5739-47, 2004 Jul 29. PMID: 15221004
Hattrup, C. L., J. Fernandez-Rodriguez, J. A. Schroeder, G. C. Hansson, and S. J. Gendler, "MUC1 can interact with adenomatous polyposis coli in breast cancer.", Biochem Biophys Res Commun, vol. 316, issue 2, pp. 364-9, 2004 Apr 02. PMID: 15020226

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