Joyce Schroeder

Professor, Molecular and Cellular Biology
Professor, BIO5 Institute
Professor, Cancer Biology - GIDP
Professor, Genetics - GIDP

My research interests are in the area of breast cancer progression and invasion. Transgenic mouse models of spontaneous carcinoma are used to understand the molecular mechanisms of primary tumor development and metastatic progression. Tumor growth and invasion is a complex process requiring the use of animal models to accurately recapitulate tumor formation and spread so that we can properly investigate the molecular mechanisms of cancer.

My work focuses on investigating the mechanisms by which erbB (EGFR) activity is modified in cancer, including interactions with MUC1 and CD44. She also explores changes in polarity that occurs between normal and transformed epithelium. To fully understand the molecular changes that occur in cancer, my research also focuses on these molecules as they affect the development and function of the normal mammary gland. My lab is also working towards the development of peptide-based therapies to block tumor-promoting protein-protein interactions as cancer therapeutics.



Atwell, B., C-Y. Chen, M. Christofferson, W. R. Montfort, and J. Schroeder, "Sorting nexin-dependent therapeutic targeting of oncogenic epidermal growth factor receptor.", Cancer Gene Ther, 2022 Oct 17. PMCID: 5004067 PMID: 36253541
Tsutsumi, E., J. Stricklin, E. A. Peterson, J. A. Schroeder, and S. Kim, "Cxcl10 Chemokine Induces Migration of ING4-Deficient Breast Cancer Cells via a Novel Cross Talk Mechanism between the Cxcr3 and Egfr Receptors.", Mol Cell Biol, vol. 42, issue 2, pp. e0038221, 2022 Feb 17. PMCID: PMC8852701 PMID: 34871062


Maisel, S. A., D. Broka, B. Atwell, T. Bunch, R. Kupp, S. K. Singh, S. Mehta, and J. Schroeder, "Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer.", J Transl Med, vol. 17, issue 1, pp. 201, 2019 06 18. PMCID: PMC6582486 PMID: 31215437


Daniel, S. G., A. D. Russ, K. M. Guthridge, A. I. Raina, P. S. Estes, L. M. Parsons, H. E. Richardson, J. A. Schroeder, and D. C. Zarnescu, "mediates the role of Lethal giant larvae as an epithelial growth inhibitor in .", Biol Open, vol. 7, issue 1, 2018 Jan 26. PMCID: PMC5829493 PMID: 29361610
Maisel, S., D. Broka, and J. Schroeder, "Intravesicular epidermal growth factor receptor subject to retrograde trafficking drives epidermal growth factor-dependent migration.", Oncotarget, vol. 9, issue 5, pp. 6463-6477, 2018 Jan 19. PMCID: PMC5814225 PMID: 29464085


Greenwood, E., S. Maisel, D. Ebertz, A. Russ, R. Pandey, and J. Schroeder, "Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration.", Oncotarget, vol. 7, issue 38, pp. 60776-60792, 2016 Sep 20. PMCID: PMC5308616 PMID: 27542214
Buehler, J., S. Zeltzer, J. Reitsma, A. Petrucelli, M. Umashankar, M. Rak, P. Zagallo, J. Schroeder, S. Terhune, and F. Goodrum, "Opposing Regulation of the EGF Receptor: A Molecular Switch Controlling Cytomegalovirus Latency and Replication.", PLoS Pathog, vol. 12, issue 5, pp. e1005655, 2016 05. PMCID: PMC4878804 PMID: 27218650


Zheng, X., L. Jiang, J. Schroeder, A. Stopeck, and Y. Zohar, "Isolation of viable cancer cells in antibody-functionalized microfluidic devices.", Biomicrofluidics, vol. 8, issue 2, pp. 024119, 2014 Mar. PMCID: PMC4008759 PMID: 24803968


Hart, M. R., H-Y. Su, D. Broka, A. Goverdhan, and J. A. Schroeder, "Inactive ERBB receptors cooperate with reactive oxygen species to suppress cancer progression.", Mol Ther, vol. 21, issue 11, pp. 1996-2007, 2013 Nov. PMCID: PMC3831044 PMID: 24081029
Horm, T. M., and J. A. Schroeder, "MUC1 and metastatic cancer: expression, function and therapeutic targeting.", Cell Adh Migr, vol. 7, issue 2, pp. 187-98, 2013 Mar-Apr. PMCID: PMC3954031 PMID: 23303343


Russ, A., J. M. V. Louderbough, D. Zarnescu, and J. A. Schroeder, "Hugl1 and Hugl2 in mammary epithelial cells: polarity, proliferation, and differentiation.", PLoS One, vol. 7, issue 10, pp. e47734, 2012. PMCID: PMC3479147 PMID: 23110097
Horm, T. M., B. G. Bitler, D. M. Broka, J. M. Louderbough, and J. A. Schroeder, "MUC1 drives c-Met-dependent migration and scattering.", Mol Cancer Res, vol. 10, issue 12, pp. 1544-54, 2012 Dec. PMCID: PMC3528822 PMID: 23193156


Zheng, X., L. Siu- Lun Cheung, J. A. Schroeder, L. Jiang, and Y. Zohar, "A high-performance microsystem for isolating circulating tumor cells.", Lab Chip, vol. 11, issue 19, pp. 3269-76, 2011 Oct 07. PMCID: PMC6765387 PMID: 21837324
Louderbough, J. M. V., J. A. Brown, R. B. Nagle, and J. A. Schroeder, "CD44 Promotes Epithelial Mammary Gland Development and Exhibits Altered Localization during Cancer Progression.", Genes Cancer, vol. 2, issue 8, pp. 771-81, 2011 Aug. PMCID: PMC3278897 PMID: 22393462
Louderbough, J. M. V., and J. A. Schroeder, "Understanding the dual nature of CD44 in breast cancer progression.", Mol Cancer Res, vol. 9, issue 12, pp. 1573-86, 2011 Dec. PMID: 21970856
Zheng, X., L. Siu- Lun Cheung, J. A. Schroeder, L. Jiang, and Y. Zohar, "Cell receptor and surface ligand density effects on dynamic states of adhering circulating tumor cells.", Lab Chip, vol. 11, issue 20, pp. 3431-9, 2011 Oct 21. PMCID: PMC6765388 PMID: 21853194


Bitler, B. G., A. Goverdhan, and J. A. Schroeder, "MUC1 regulates nuclear localization and function of the epidermal growth factor receptor.", J Cell Sci, vol. 123, issue Pt 10, pp. 1716-23, 2010 May 15. PMCID: PMC2864713 PMID: 20406885
Louderbough, J. M. V., J. I. Lopez, and J. A. Schroeder, "Matrix hyaluronan alters epidermal growth factor receptor-dependent cell morphology.", Cell Adh Migr, vol. 4, issue 1, pp. 26-31, 2010 Jan-Mar. PMCID: PMC2852554 PMID: 20009574
Flowers, M., J. A. Schroeder, A. D. Borowsky, D. G. Besselsen, C. A. Thomson, R. Pandey, and P. A. Thompson, "Pilot study on the effects of dietary conjugated linoleic acid on tumorigenesis and gene expression in PyMT transgenic mice.", Carcinogenesis, vol. 31, issue 9, pp. 1642-9, 2010 Sep. PMCID: PMC2930807 PMID: 20624750
Bitler, B. G., and J. A. Schroeder, "Anti-cancer therapies that utilize cell penetrating peptides.", Recent Pat Anticancer Drug Discov, vol. 5, issue 2, pp. 99-108, 2010 Jun. PMCID: PMC7485746 PMID: 19961434


Bitler, B. G., I. Menzl, C. L. Huerta, B. Sands, W. Knowlton, A. Chang, and J. A. Schroeder, "Intracellular MUC1 peptides inhibit cancer progression.", Clin Cancer Res, vol. 15, issue 1, pp. 100-9, 2009 Jan 01. PMCID: PMC2676873 PMID: 19118037
Cheung, L. Siu Lun, X. Zheng, A. Stopa, J. C. Baygents, R. Guzman, J. A. Schroeder, R. L. Heimark, and Y. Zohar, "Detachment of captured cancer cells under flow acceleration in a bio-functionalized microchannel.", Lab Chip, vol. 9, issue 12, pp. 1721-31, 2009 Jun 21. PMID: 19495456


Pochampalli, M. R., B. G. Bitler, and J. A. Schroeder, "Transforming growth factor alpha dependent cancer progression is modulated by Muc1.", Cancer Res, vol. 67, issue 14, pp. 6591-8, 2007 Jul 15. PMID: 17638868
Pochampalli, M. R., R. M. el Bejjani, and J. A. Schroeder, "MUC1 is a novel regulator of ErbB1 receptor trafficking.", Oncogene, vol. 26, issue 12, pp. 1693-701, 2007 Mar 15. PMID: 16983337


Lopez, J. I., T. D. Camenisch, M. V. Stevens, B. J. Sands, J. McDonald, and J. A. Schroeder, "CD44 attenuates metastatic invasion during breast cancer progression.", Cancer Res, vol. 65, issue 15, pp. 6755-63, 2005 Aug 01. PMID: 16061657