Joyce Schroeder

Professor, Molecular and Cellular Biology
Professor, BIO5 Institute
Professor, Cancer Biology - GIDP
Professor, Genetics - GIDP

My research interests are in the area of breast cancer progression and invasion. Transgenic mouse models of spontaneous carcinoma are used to understand the molecular mechanisms of primary tumor development and metastatic progression. Tumor growth and invasion is a complex process requiring the use of animal models to accurately recapitulate tumor formation and spread so that we can properly investigate the molecular mechanisms of cancer.

My work focuses on investigating the mechanisms by which erbB (EGFR) activity is modified in cancer, including interactions with MUC1 and CD44. She also explores changes in polarity that occurs between normal and transformed epithelium. To fully understand the molecular changes that occur in cancer, my research also focuses on these molecules as they affect the development and function of the normal mammary gland. My lab is also working towards the development of peptide-based therapies to block tumor-promoting protein-protein interactions as cancer therapeutics.



Hattrup, C. L., J. Fernandez-Rodriguez, J. A. Schroeder, G. C. Hansson, and S. J. Gendler, "MUC1 can interact with adenomatous polyposis coli in breast cancer.", Biochem Biophys Res Commun, vol. 316, issue 2, pp. 364-9, 2004 Apr 02. PMID: 15020226
Schroeder, J. A., A. Al Masri, M. C. Adriance, J. C. Tessier, K. L. Kotlarczyk, M. C. Thompson, and S. J. Gendler, "MUC1 overexpression results in mammary gland tumorigenesis and prolonged alveolar differentiation.", Oncogene, vol. 23, issue 34, pp. 5739-47, 2004 Jul 29. PMID: 15221004


Schroeder, J. A., L. F. Jackson, D. C. Lee, and T. D. Camenisch, "Form and function of developing heart valves: coordination by extracellular matrix and growth factor signaling.", J Mol Med (Berl), vol. 81, issue 7, pp. 392-403, 2003 Jul. PMID: 12827270
Schroeder, J. A., M. C. Adriance, M. C. Thompson, T. D. Camenisch, and S. J. Gendler, "MUC1 alters beta-catenin-dependent tumor formation and promotes cellular invasion.", Oncogene, vol. 22, issue 9, pp. 1324-32, 2003 Mar 06. PMID: 12618757


Camenisch, T. D., J. A. Schroeder, J. Bradley, S. E. Klewer, and J. A. McDonald, "Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors.", Nat Med, vol. 8, issue 8, pp. 850-5, 2002 Aug. PMID: 12134143


Schroeder, J. A., M. C. Thompson, M. M. Gardner, and S. J. Gendler, "Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland.", J Biol Chem, vol. 276, issue 16, pp. 13057-64, 2001 Apr 20. PMID: 11278868


Schroeder, J. A., K. L. Troyer, and D. C. Lee, "Cooperative induction of mammary tumorigenesis by TGFalpha and Wnts.", Oncogene, vol. 19, issue 28, pp. 3193-9, 2000 Jun 29. PMID: 10918574


Schroeder, J. A., and D. C. Lee, "Dynamic expression and activation of ERBB receptors in the developing mouse mammary gland.", Cell Growth Differ, vol. 9, issue 6, pp. 451-64, 1998 Jun. PMID: 9663464


Schroeder, J. A., and D. C. Lee, "Transgenic mice reveal roles for TGFalpha and EGF receptor in mammary gland development and neoplasia.", J Mammary Gland Biol Neoplasia, vol. 2, issue 2, pp. 119-29, 1997 Apr. PMID: 10882298


Berkowitz, E. A., K. B. Seroogy, J. A. Schroeder, W. E. Russell, E. P. Evans, R. F. Riedel, H. K. Phillips, C. A. Harrison, D. C. Lee, and N. C. Luetteke, "Characterization of the mouse transforming growth factor alpha gene: its expression during eyelid development and in waved 1 tissues.", Cell Growth Differ, vol. 7, issue 9, pp. 1271-82, 1996 Sep. PMID: 8877107


Sandgren, E. P., J. A. Schroeder, T. H. Qui, R. D. Palmiter, R. L. Brinster, and D. C. Lee, "Inhibition of mammary gland involution is associated with transforming growth factor alpha but not c-myc-induced tumorigenesis in transgenic mice.", Cancer Res, vol. 55, issue 17, pp. 3915-27, 1995 Sep 01. PMID: 7641211


Schluter, S. F., J. Schroeder, E. Wang, and J. J. Marchalonis, "Recognition molecules and immunoglobulin domains in invertebrates.", Ann N Y Acad Sci, vol. 712, pp. 74-81, 1994 Apr 15. PMID: 8192354


Akins, J. M., J. A. Schroeder, D. L. Brower, and H. V. Aposhian, "Evaluation of Drosophila melanogaster as an alternative animal for studying the neurotoxicity of heavy metals.", Biometals, vol. 5, issue 2, pp. 111-20, 1992 Summer. PMID: 1525477