Associate Professor, Molecular Biology and Genetics Department, Johns Hopkins University School of Medicine
"A fundamental property of living cells is their ability to sense and respond to a changing environment. This versatility is achieved through highly interconnected signaling networks that have been carefully characterized through genetic and biochemical approaches. However, the temporal organization of signaling activities during cell fate decisions remains poorly understood. In order to address these questions, live single cell measurements of signaling and cell fate decisions are critical. In our laboratory we use live cell imaging of genetically encoded biosensors to characterize the temporal organization of signaling activities during mammalian development and tumorigenesis. Specifically, I will discuss our most recent work regarding the role of MAPK signaling network dynamics in preimplantation development and the early stages of cancer."
Faculty Host: Dr. Andrew Paek (MCB)