Biophysical characterization of synthetic adhesins for predicting and tuning engineered living material properties​

Costan, S. A., Ryan, P. M., Kim, H., Wolgemuth, C., Riedel-Kruse, I. H.

Synthetic biology is increasingly integrating into material science, where the ability to tune and predict material properties is a key component, especially in the context of 3D printing. This paper presents the quantitative characterization of a bacterial synthetic adhesion toolbox through several biophysical methods. Using these parameters, it is then demonstrated how to predict and quantitatively tune the macroscopic properties of engineered living materials consisting of cells expressing these synthetic adhesins, which is essential for applications such as bioprinting.

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