Age is the primary risk factor for the most prominent diseases in modern society—cardiovascular disease, cancer, diabetes, stroke, neurodegeneration. By understanding the molecular processes that drive aging we can identify therapeutic targets to treat or prevent multiple classes of disease simultaneously and extend healthy human lifespan. MCB researchers are studying many areas of biology that will shape our understanding of the mechanisms of aging: genetic and environmental determinants of longevity, the role of metabolism in aging, mechanisms of cell-fate decisions (apoptosis, quiescence, senescence), and inflammation. We seek to apply knowledge of how these basic aging processes drive specific forms of age-associated pathology and develop new treatments, including for diseases such as cancer and Alzheimer's disease.
Faculty with primary research interest: Ross Buchan, Pascale Charest, Joyce Schroeder, George Sutphin, Ted Weinert, Guang Yao
Faculty with secondary research interest: Andrew Capaldi, Nancy Horton, Keith Maggert, Lisa Nagy, Megha Padi, Andrew Paek, Corin Gray