When
Where
Biosciences West, Room 208
Presenter Details
Dr. Guang Yao, Associate Professor, Molecular & Cellular Biology, UArizona
You can read more at the Yao Lab Website
Seminar Information
Most cells in the human body exist in dormant rather than proliferative states. Among these non-dividing cells, quiescence represents a reversible "sleeping" state—encompassing tissue-resident stem cells, fibroblasts, and immune cells that await reactivation for tissue maintenance and repair. Senescence, conversely, has traditionally been characterized as a permanent cell cycle exit triggered by various stressors in proliferating cells. While conventional wisdom suggested that exiting the cell cycle into quiescence protected cells from stress-induced senescence, our recent research reveals a more nuanced relationship. We have uncovered mechanistic connections and blurred boundaries between these two dormancy states. Through integrated modeling and experimental approaches, we explore the profound implications of this finding for tissue regeneration capacity, cancer dormancy mechanisms, and the progression of age-related pathologies.
Seminar Host
Dr. Lisa Nagy (MCB)