MCB Joint Seminar Series: Curtis Thorne "Colorectal Cancer: Drugging the impossible and the Lazarus Principle"

This seminar will be divided into two complementary parts that highlight my lab's work in both therapeutic and diagnostic development in colorectal cancer. In Part I, I will focus on targeting the WNT signaling pathway in CRC, emphasizing new strategies to disrupt oncogenic WNT/β-catenin activity and cancer stem cell maintenance. In Part II, I will shift to re-envisioning diagnostic biomarkers in CRC, discussing how patient-derived organoid-driven and single-cell imaging approaches can redefine how we detect, stratify, and predict therapeutic responses in patients.