When
Where
Harvill, Room 204
Presenter Details
Pieter Dorrestein, Professor of Pharmacology and Pediatrics, UCSD, Director of the Collaborative Mass Spectrometry Innovation Center & Co-Director of the Institute for Metabolomics Medicine
Seminar Information
In recent years, there has been a growth in the deposition of data into public repositories like Metabolights, Metabolomics Workbench, MetaboBank, and GNPS-MassIVE, reflecting a trend towards data sharing. Still, depositors often question the impact of their contributions due to the perceived lack of effective tools for data reuse. Fortunately, ongoing efforts in indexing mass spectrometry data and metadata are enhancing the feasibility of extracting valuable insights and making new discoveries from publicly deposited data. This presentation will highlight the advancements made in enabling efficient searching and discovery of biological findings and novel molecules on a repository scale, which now has grown to well over a billion MS/MS spectra. Demonstrating the applications of leveraging public data mining, we will highlight the discovery of 10,000s new microbiota derived metabolites. We not only highlight the discovery but also their associations with health conditions, diet and other interventions, diseases, and how this capability even helped in the analysis of metabolites on the international space station. The indexing and development of search tools that enable aggregated analysis of repository data, comprising millions of files represent an important step into the emerging Big Data era in metabolomics. This transition facilitates the integration of data collected in individual laboratories with public datasets, thereby fostering the emergence of new insights. Such a shift is expected to shape a substantial portion of the metabolomics field in the forthcoming decade.
Seminar Host
Beckman Scholars, UArizona