Understanding the molecular and cellular mechanisms of disease is one of the key goals of modern biomedical research, and MCB labs are working to understand cancer, neurodegeneration and aging. We investigate the mechanisms of genomic instability, signal transduction and the networks of cellular responses to the extracellular cues leading to cell survival. We are using these insights to design better treatments for cancer and discover new therapies. Furthermore, our basic understanding of cellular function and trafficking is uncovering translational openings for neurodegenerative diseases such as ALS.