Molecular & Cellular Biology

Revealing the secrets of nature & educating next generation of science innovators

Cell Signaling, Trafficking, and Polarity

Cell Signaling, Trafficking, and Polarity

Each living cell senses and integrates external cues and makes corresponding responses. The cellular responses are mediated by a complex network of intertwined signalling pathways and molecular transport systems in the cell. Cell polarity is one type of cellular response, by which a cell exhibits spatial differences or "unevenness" in its structure and content, to enable specific cellular functions. Misregulation of cell signalling, trafficking, and polarity is a major cause of a wide range of disorders in living organisms.

Associated Faculty

The control of gene expression is critical to nearly all aspects of cellular biology, from maintaining basic cell function and identity, to the ability of cells to respond to numerous signals that arise during processes such as development, exposure to pathogens or changes in the cellular environment.... Read More
Andrew Capaldi, PhD, researches the signaling pathways and transcription factors in a cell that are organized into circuits. They allow cells to process information and make decisions. For Dr. Capaldi, the work arises in understanding both how these circuits are built from their components, and how they... Read More
The trafficking of macromolecules between different compartments is an essential process in all eukaryotic cells and is used to maintain cellular integrity, to interact with the extracellular environment, and to generally modulate various cellular activities. Numerous advances have been made in... Read More
Our research group integrates computational systems biology and population genetics to understand the function and evolution of the complex molecular networks that underlie life. We build and analyze mathematical simulations of protein networks to probe deeper into their function than experiments can. We... Read More
I am interested in exploring the genetic basis of morphological diversity. To do this, I ask how developmental regulatory networks known to pattern a particular aspect of morphology in one organism are modified in other related organisms. At the moment, the focus of the lab is on the evolution of arthropod... Read More
Understanding the heterogeneous response of cancer cells to chemotherapy treatment Isogenic populations of cells often show very different responses to identical perturbations. For cancer cells this can manifest in a fractional response to chemotherapy treatment. We use quantitative fluorescence microscopy... Read More
Joyce Schroeder, PhD, holds research interests in the area of breast cancer progression and invasion. Transgenic mouse models of spontaneous carcinoma are used to understand the molecular mechanisms of primary tumor development and metastatic progression. Tumor growth and invasion is a complex process... Read More
Frans Tax, PhD, understands plants grow as a result of the proliferation of stem cells and the establishment and maintenance of defined developmental fates in progeny cells. The major goal is to elucidate general molecular mechanisms used by plants to specify and maintain cell fates, ranging from stem cells... Read More
What do we do? We study gene networks that control life and death decisions of cancer cells, and how they differ from normal cells. What is the goal of our research? We aim to better understand control mechanisms underlying various cell-fate decisions, and their connections to cancer development and aging,... Read More
1. Translational control in glia-neural stem cell interactions We have recently discovered a novel role for the RNA binding protein, FMRP, in neural stem cells exit from quiescence, a universal mechanism utilized by stem and progenitor cells across phyla. Furthermore, using tissue specific RNAi we found... Read More