Xia Wang

Postdoctoral Research Associate II, Molecular and Cellular Biology

I am a postdoctoral fellow in the laboratory of Professor Guang Yao.

Summary of My Work:

I apply bioinformatics and statistical machine learning tools (in collaboration with Prof. Helen Zhang at UA Math/Stat), as well as molecular and cellular biology methods, to study the Rb-E2F gene network controlling the quiescent states of stem and progenitor cells. Many cellular factors and mechanisms affect quiescence depth by impinging on the Rb-E2F bistable switch and modulating its activation threshold. I am particularly interested in how circadian clock regulates cellular quiescence depth.

I am currently working on two projects.

(1) Using systems biology approaches to investigate the molecular mechanisms by which circadian clock modulates the cell cycle and related cellular processes.

(2) Identify microRNA biomarkers for the early detection of ovarian cancer. In this project, I perform next-gen microRNA-seq analysis of clinical samples (in collaboration with Prof. Setsuko Chambers in UA Cancer Center) to identify microRNA profiles (both tissue- and blood-based) suggestive of high-risk ovarian cancer patients based on machine learning and feature selection methods.
 

Publications

2018

Kwon, J. Sarah, X. Wang, and G. Yao, "Study Quiescence Heterogeneity by Coupling Single-Cell Measurements and Computer Modeling.", Methods Mol Biol, vol. 1686, pp. 287-299, 2018. PMID: 29030828

2017

Kwon, J. Sarah, N. J. Everetts, X. Wang, W. Wang, K. Della Croce, J. Xing, and G. Yao, "Controlling Depth of Cellular Quiescence by an Rb-E2F Network Switch.", Cell Rep, vol. 20, issue 13, pp. 3223-3235, 2017 Sep 26. PMCID: PMC6571029 PMID: 28954237
Wang, X., K. Fujimaki, G. C. Mitchell, J. Sarah Kwon, K. Della Croce, C. Langsdorf, H. Helen Zhang, and G. Yao, "Exit from quiescence displays a memory of cell growth and division.", Nat Commun, vol. 8, issue 1, pp. 321, 2017 08 22. PMCID: PMC5567331 PMID: 28831039
Dai, J., M. A. Miller, N. J. Everetts, X. Wang, P. Li, Y. Li, J-H. Xu, and G. Yao, "Elimination of quiescent slow-cycling cells via reducing quiescence depth by natural compounds purified from Ganoderma lucidum.", Oncotarget, vol. 8, issue 8, pp. 13770-13781, 2017 Feb 21. PMCID: PMC5355137 PMID: 28099150