Teal Brechtel, BS, Biology, 2012, Millsaps College

MCB Program Start:

2013

Undergrad:

BS Biology, Millsaps College, 2012

Research Advisor and Department:                                     

Dr. Tricia Serio, BMCB

Research Topic:                                                                            

Some proteins have the ability to access multiple conformations including a native fold and an amyloid fold.  In the amyloid conformation these proteins aggregate into amyloid aggregates that disrupt protein homeostasis within cells. This disruption in protein homeostasis increases the likelihood that other proteins will form amyloid aggregates.  My research focuses on finding the key players in protein homeostasis that determine whether an amyloid is likely to form.

Lab Rotations:

Dr. Franz Tax

Dr. Guang Yao                         

Honors and Awards:

BMCB NRSA Training Grant (2015-2017)
Honorable Mention, NSF GRFP (2015)
Galileo Circle Scholarship (2016)
College of Science Service Award (2016)
College of Science Teaching Award (2017)

Publications:

Archer, M., Davis, L., Brechtel, T. M., Davis, L. E., Parmar, R. C., Hasan, M. H. & Tandon, R. (2017) Inhibition of endocytic pathways impacts cytomegalovirus maturation. Scientific Reports 7(46069). 

Brechtel, T. M., Mocarski, E. S., & Tandon, R. (2014). Highly Acidic C-Terminal Region of Cytomegalovirus pUL96 Determines Its Functions during Virus Maturation Independently of a Direct pp150 Interaction. Journal of virology, 88(8), 4493–4503. http://jvi.asm.org/cgi/doi/10.1128/JVI.03784-13

Brechtel, T. M., Tyner, M., & Tandon, R. (2013). Complete Genome Sequence of a UL96 Mutant Cytomegalovirus Towne-BAC (Bacterial Artificial Chromosome) Isolate Passaged in Fibroblasts To Allow Accumulation of Compensatory Mutations. Genome announcements, 1(5). http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id...

Brechtel, T., Tyner, M., & Tandon, R. (2013). Complete Genome Sequence of a Cytomegalovirus Towne-BAC (Bacterial Artificial Chromosome) Isolate Maintained in Escherichia coli for 10 Years and Then Serially Passaged in Human Fibroblasts. Genome announcements, 1(5). http://www.ncbi.nlm.nih.gov/pubmed/24072857

Supervisor: