Elizabeth Jose, MS, Microbiology and Natural Sciences

MCB PhD Student
Department: 
MCB

MCB Program Start:

2019

Undergrad Degree
MS Microbilogy, MS Natural Sciences 

Research Advisor and Department
Andrew Paek - MCB

Research Interests:

The p53 and Forkhead Box O (FOXO) proteins are transcription factors that have a striking number of similarities despite their distinct evolutionary origins. Both p53 and FOXO are activated in response to a range of cellular stresses and upon activation upregulate genes in overlapping pathways including cell-cycle arrest and apoptosis. Both FOXO and p53 are tumor suppressors that are frequently downregulated in cancer. I am interested in determining the relationship between FOXOs and p53 after treatment with ROS inducing agents like hydrogen peroxide. I want to determine which protein responds to hydrogen peroxide and how this response changes over time. This will help in understanding how cells make fate decisions. I want to understand how cells coordinate the activation of these two pathways to determine if they are to live or die. 

Hobbies and Interests
Hiking, cooking, playing guitar

Outreach and Service Activities

UBRP Small Group Leader
BECUR poster judge
Volunteer at Tucson Festival of Books
ABBS Graduate Student Recruitment Volunteer
Science Speak Easy
Volunteer with Molly Bolger 
   

 

Publications

2021

Koenig, S. N., H. C. Sucharski, E. Jose, E. K. Dudley, F. Madiai, O. Cavus, A. D. Argall, J. Williams, N. P. Murphy, C. Br Keith, et al., "Inherited Variants in SCARB1 Cause Severe Early-Onset Coronary Artery Disease.", Circ Res, 2021 May 12. PMID: 33975440

2018

Das, A., S. Datta, E. Roche, S. Chaffee, E. Jose, L. Shi, K. Grover, S. Khanna, C. K. Sen, and S. Roy, "Novel mechanisms of Collagenase Santyl Ointment (CSO) in wound macrophage polarization and resolution of wound inflammation.", Sci Rep, vol. 8, issue 1, pp. 1696, 2018 01 26. PMCID: PMC5786052 PMID: 29374192