Defects in THO/TREX-2 function cause accumulation of novel cytoplasmic mRNP granules that can be cleared by autophagy.

Eshleman N, Liu G, McGrath K, Parker R, Buchan J.R. "Defects in THO/TREX-2 function cause accumulation of novel cytoplasmic mRNP granules that can be cleared by autophagy." RNA. 2016;22(8):1200-14.